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KMID : 0941820070170010013
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Korean Journal of Clinical Pharmacy
2007 Volume.17 No. 1 p.13 ~ p.18
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Effect of Cimetidine on Pharmacokinetics of Theophylline in Healthy Korean Volunteers
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Kwon Jun-Tack
Chai Seok
Sohn Dong-Ryul
Yom Yoon-Ki
Kim Hyung-Kee
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Abstract
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The purpose of the present study was to investigate the effect of cimetidine on theophylline pharmacokinetics in Korean healthy normal subjects. Eight subjects were enrolled and open label, two period cross-over study was conducted without significant drug related adverse reactions. Cimetidine seemed that significantly inhibited the metabolism of theophylline, oral clearance decreased significantly when cimetidine was coadministered. Coadministered cimetidine increased and of theophylline. All subjects were genotyped using PCR-RFLP methods to evaluate the differences in metabolic capacity in accordance with CYP1A2 genotypes, but no mutant genotype was found. This suggests that metabolic capacities were not significantly affected by CYP1A2 genotypes among subjects. In conclusion, disposition of theophylline was significantly affected by coadministered cimetidine. Further evaluation with well-designed drug interaction study in accordance with various genotype of CYP1A2 is needed.
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KEYWORD
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cimetidine, theophylline, CYP1A2, druginteraction, pharmacokinetics
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